NFATC4 explained

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.^{[1] [2]}

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.^[2]

Interactions

NFATC4 has been shown to interact with CREB-binding protein.^[3]

See also

• NFAT

References

Further reading

• Rao A, Luo C, Hogan PG . Transcription factors of the NFAT family: regulation and function . Annual Review of Immunology . 15 . 707–47 . 1997 . 9143705 . 10.1146/annurev.immunol.15.1.707 .
• Crabtree GR . Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT . Cell . 96 . 5 . 611–4 . Mar 1999 . 10089876 . 10.1016/S0092-8674(00)80571-1 . 8817053 . free .
• Horsley V, Pavlath GK . NFAT: ubiquitous regulator of cell differentiation and adaptation . The Journal of Cell Biology . 156 . 5 . 771–4 . Mar 2002 . 11877454 . 2173310 . 10.1083/jcb.200111073 .
• Jabado N, Le Deist F, Fisher A, Hivroz C . Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity . European Journal of Immunology . 24 . 11 . 2646–52 . Nov 1994 . 7957556 . 10.1002/eji.1830241112 . 30435577 .
• Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A . Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif . Biochemical and Biophysical Research Communications . 205 . 1 . 467–74 . Nov 1994 . 7999066 . 10.1006/bbrc.1994.2689 .
• Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT . Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering . European Journal of Immunology . 26 . 9 . 2181–8 . Sep 1996 . 8814265 . 10.1002/eji.1830260933 . 23430217 .
• Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN . A calcineurin-dependent transcriptional pathway for cardiac hypertrophy . Cell . 93 . 2 . 215–28 . Apr 1998 . 9568714 . 10.1016/S0092-8674(00)81573-1 . 4459646 .
• Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG . Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT . Molecular Cell . 1 . 5 . 627–37 . Apr 1998 . 9660947 . 10.1016/S1097-2765(00)80063-5 . free .
• Chow CW, Davis RJ . Integration of calcium and cyclic AMP signaling pathways by 14-3-3 . Molecular and Cellular Biology . 20 . 2 . 702–12 . Jan 2000 . 10611249 . 85175 . 10.1128/MCB.20.2.702-712.2000 .
• Graef IA, Chen F, Chen L, Kuo A, Crabtree GR . Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature . Cell . 105 . 7 . 863–75 . Jun 2001 . 11439183 . 10.1016/S0092-8674(01)00396-8 . 5278706 . free .
• Yang T, Davis RJ, Chow CW . Requirement of two NFATc4 transactivation domains for CBP potentiation . The Journal of Biological Chemistry . 276 . 43 . 39569–76 . Oct 2001 . 11514544 . 10.1074/jbc.M102961200 . free .
• Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW . Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases . Molecular and Cellular Biology . 22 . 11 . 3892–904 . Jun 2002 . 11997522 . 133816 . 10.1128/MCB.22.11.3892-3904.2002 .
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E . Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha . Virology . 303 . 1 . 174–80 . Nov 2002 . 12482669 . 10.1006/viro.2002.1676 . free .
• Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR . Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons . Cell . 113 . 5 . 657–70 . May 2003 . 12787506 . 10.1016/S0092-8674(03)00390-8 . 18024622 . free .
• Lahti AL, Manninen A, Saksela K . Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB . Virology . 310 . 1 . 190–6 . May 2003 . 12788643 . 10.1016/S0042-6822(03)00164-8 .

Notes and References

1. Hoey T, Sun YL, Williamson K, Xu X . Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins . Immunity . 2 . 5 . 461–72 . May 1995 . 7749981 . 10.1016/1074-7613(95)90027-6 . free .
2. Web site: Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4.
3. Yang T, Davis RJ, Chow CW . Requirement of two NFATc4 transactivation domains for CBP potentiation . The Journal of Biological Chemistry . 276 . 43 . 39569–76 . Oct 2001 . 11514544 . 10.1074/jbc.M102961200 . free .