NFAM1 explained

NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene.^[1]

Function

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].

Further reading

• Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z . Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway . J. Biol. Chem. . 278 . 19 . 16797–801 . May 2003 . 12615919 . 10.1074/jbc.M211060200 . free .
• Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF . Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation . Am. J. Physiol., Cell Physiol. . 292 . 3 . C1167–78 . March 2007 . 17079331 . 10.1152/ajpcell.00590.2005 .
• Manley K, O'Hara BA, Atwood WJ . Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection . Virology . 372 . 1 . 48–55 . March 2008 . 18031784 . 2289909 . 10.1016/j.virol.2007.10.029 .

Notes and References

1. Web site: Entrez Gene: NFAT activating protein with ITAM motif 1. 2018-03-13.