NEURL2 explained
Neuralized-like protein 2 is a protein that in humans is encoded by the NEURL2 gene.[1] [2]
Function
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.[2]
See also
Further reading
- Song R . Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1 . J. Biol. Chem. . 281 . 47 . 36391–400 . 2007 . 17003037 . 10.1074/jbc.M606601200 . Koo BK . Yoon KJ . Yoon . M.-J. . Yoo . K.-W. . Kim . H.-T. . Oh . H.-J. . Kim . Y.-Y. . Han . J.-K. . free.
- Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Nastasi T . Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis . Dev. Cell . 6 . 2 . 269–82 . 2004 . 14960280 . 10.1016/S1534-5807(04)00020-6 . Bongiovanni A . Campos Y . Mann . Linda . Toy . James N . Bostrom . Jake . Rottier . Robbert . Hahn . Christopher . Conaway . Joan Weliky . free .
- Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
Notes and References
- Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ . The SOCS box: a tale of destruction and degradation . Trends Biochem Sci . 27 . 5 . 235–41 . Jun 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 .
- Web site: Entrez Gene: NEURL2 neuralized homolog 2 (Drosophila).