Sialidase-4 Explained
Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.[1]
Function
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.[1]
Interactions
Sialidase-4 has been shown to interact with phospholipid scramblase 1.[2]
References
Further reading
- Comelli EM, Amado M, Lustig SR, Paulson JC . Identification and expression of Neu4, a novel murine sialidase. . Gene . 321 . 155–61 . 2004 . 14637003 . 10.1016/j.gene.2003.08.005 .
- Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G . Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. . Genomics . 83 . 3 . 445–53 . 2004 . 14962670 . 10.1016/j.ygeno.2003.08.019 .
- Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV . Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. . J. Biol. Chem. . 279 . 35 . 37021–9 . 2004 . 15213228 . 10.1074/jbc.M404531200 . free .
- Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J . Large-scale cDNA transfection screening for genes related to cancer development and progression. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 524842 . 10.1073/pnas.0404089101 . 2004PNAS..10115724W . free .
- Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV . Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. . FEBS J. . 272 . 10 . 2545–56 . 2005 . 15885103 . 10.1111/j.1742-4658.2005.04679.x . 27379898 . free .
Notes and References
- Web site: Entrez Gene: NEU4 sialidase 4.
- Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .