NEO1 explained
Neogenin is a protein that in humans is encoded by the NEO1 gene.[1] [2]
Interactions
NEO1 has been shown to interact with PTK2.[3] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. [4]
Further reading
- Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ . Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. . J. Cell Biol. . 127 . 6 Pt 2 . 2009–20 . 1995 . 7806578 . 2120299 . 10.1083/jcb.127.6.2009 .
- Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M . Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. . Cell . 87 . 2 . 175–85 . 1996 . 8861902 . 10.1016/S0092-8674(00)81336-7 . free .
- Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ . Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23. . Genomics . 41 . 3 . 414–21 . 1997 . 9169140 . 10.1006/geno.1997.4688 .
- Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M . Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. . J. Neurosci. . 19 . 12 . 4938–47 . 1999 . 10366627 . 10.1523/JNEUROSCI.19-12-04938.1999. 6782680 . free .
- Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L . Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. . Dev. Cell . 4 . 3 . 371–82 . 2003 . 12636918 . 10.1016/S1534-5807(03)00054-6 . free .
- Ho SM, Lau KM, Mok SC, Syed V . Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. . Oncogene . 22 . 27 . 4243–56 . 2003 . 12833147 . 10.1038/sj.onc.1206437 . free .
- Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A . RGM and its receptor neogenin regulate neuronal survival. . Nat. Cell Biol. . 6 . 8 . 749–55 . 2004 . 15258591 . 10.1038/ncb1157 . 15433313 .
- Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC . Focal adhesion kinase in netrin-1 signaling. . Nat. Neurosci. . 7 . 11 . 1204–12 . 2005 . 15494733 . 10.1038/nn1330 . 2901216 .
- Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY . Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer. . BMC Cancer . 5 . 154 . 2006 . 16324219 . 1322231 . 10.1186/1471-2407-5-154 . free .
- Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 1850943 . 10.1021/pr0502065 .
Notes and References
- Meyerhardt JA, Look AT, Bigner SH, Fearon ER . Identification and characterization of neogenin, a DCC-related gene . Oncogene . 14 . 10 . 1129–36 . Apr 1997 . 9121761 . 10.1038/sj.onc.1200935 . free .
- Web site: Entrez Gene: NEO1 neogenin homolog 1 (chicken).
- Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC . Focal adhesion kinase in netrin-1 signaling . Nat. Neurosci. . 7 . 11 . 1204–12 . Nov 2004 . 15494733 . 10.1038/nn1330 . 2901216 .
- RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway. 10.1007/s11626-021-00555-9. 2021. Do Carmo Costa. Alinne. Copola. Aline Gonçalves Lio. Carvalho e Souza. Clara. Nogueira. Júlia Meireles. Silva. Gerluza Aparecida Borges. Jorge. Erika Cristina. In Vitro Cellular & Developmental Biology - Animal. 57. 4. 415–427. 33748906. 232311370.