NELL2 explained

Protein kinase C-binding protein NELL2 is an enzyme that in humans is encoded by the NELL2 gene.^[1]

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full length sequence has not been determined.^[1]

Further reading

• Watanabe TK, Katagiri T, Suzuki M, etal . Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. . Genomics . 38 . 3 . 273–6 . 1997 . 8975702 . 10.1006/geno.1996.0628 .
• Beckmann G, Hanke J, Bork P, Reich JG . Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. . J. Mol. Biol. . 275 . 5 . 725–30 . 1998 . 9480764 . 10.1006/jmbi.1997.1510 .
• Luce MJ, Burrows PD . The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. . Gene . 231 . 1–2 . 121–6 . 1999 . 10231576 . 10.1016/S0378-1119(99)00093-1 .
• Kuroda S, Oyasu M, Kawakami M, etal . Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2 . Biochem. Biophys. Res. Commun. . 265 . 1 . 79–86 . 1999 . 10548494 . 10.1006/bbrc.1999.1638 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Web site: Entrez Gene: NELL2 NEL-like 2 (chicken).