NEIL3 explained

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.^[1]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.^[2]

See also

• OGG1
• NTHL1
• NEIL1
• NEIL2

Notes and References

1. Web site: Entrez Gene: Nei endonuclease VIII-like 3 (E. coli) .
2. Bandaru V, Sunkara S, Wallace SS, Bond JP . A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII . DNA Repair (Amst.) . 1 . 7 . 517–29 . July 2002 . 12509226 . 10.1016/S1568-7864(02)00036-8 .