NEIL2 explained

Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.^{[1] [2] [3]}

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM]^[3]

See also

• NEIL1
• NEIL3
• OGG1
• NTHL1

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Takao M, Kanno S, Kobayashi K, etal . A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. . J. Biol. Chem. . 277 . 44 . 42205–13 . 2003 . 12200441 . 10.1074/jbc.M206884200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bandaru V, Sunkara S, Wallace SS, Bond JP . A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. . DNA Repair (Amst.) . 1 . 7 . 517–29 . 2003 . 12509226 . 10.1016/S1568-7864(02)00036-8 .
• Dou H, Mitra S, Hazra TK . Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. . J. Biol. Chem. . 278 . 50 . 49679–84 . 2004 . 14522990 . 10.1074/jbc.M308658200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Katafuchi A, Nakano T, Masaoka A, etal . Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions. . J. Biol. Chem. . 279 . 14 . 14464–71 . 2004 . 14734554 . 10.1074/jbc.M400393200 . free .
• Bhakat KK, Hazra TK, Mitra S . Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. . Nucleic Acids Res. . 32 . 10 . 3033–9 . 2004 . 15175427 . 10.1093/nar/gkh632 . 434438 .
• Das A, Rajagopalan L, Mathura VS, etal . Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. . J. Biol. Chem. . 279 . 45 . 47132–8 . 2004 . 15339932 . 10.1074/jbc.M406224200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Das A, Wiederhold L, Leppard JB, etal . NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. . DNA Repair (Amst.) . 5 . 12 . 1439–48 . 2007 . 16982218 . 10.1016/j.dnarep.2006.07.003 . 2805168 .
• Broderick P, Bagratuni T, Vijayakrishnan J, etal . Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition. . BMC Cancer . 6 . 243 . 2006 . 17029639 . 10.1186/1471-2407-6-243 . 1624846 . free .
• Katafuchi A, Matsubara M, Terato H, etal . Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions. . Nucleic Acids Symp Ser (Oxf) . 48. 48 . 175–6 . 2007 . 17150535 . 10.1093/nass/48.1.175 . free .

Notes and References

1. Hazra TK, Kow YW, Hatahet Z, Imhoff B, Boldogh I, Mokkapati SK, Mitra S, Izumi T . Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions . J Biol Chem . 277 . 34 . 30417–20 . Aug 2002 . 12097317 . 10.1074/jbc.C200355200 . free .
2. Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK . Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress . J Biol Chem . 282 . 39 . 28474–84 . Sep 2007 . 17686777 . 2679419 . 10.1074/jbc.M704672200 . free .
3. Web site: Entrez Gene: NEIL2 nei like 2 (E. coli).