NEDD1 explained

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene^[1] and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

Further reading

• Pinyol R, Scrofani J, Vernos I . The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function. . Curr. Biol. . 23 . 2 . 143–9 . 2012 . 23273898 . 10.1016/j.cub.2012.11.046. free . 10230/23504 . free .
• Sdelci S, Schütz M, Pinyol R, etal . Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome. . Curr. Biol. . 22 . 16 . 1516–23 . 2012 . 22818914 . 10.1016/j.cub.2012.06.027 . free . 2012CBio...22.1516S .
• Haren L, Remy MH, Bazin I, etal . NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. . J. Cell Biol. . 172 . 4 . 505–15 . 2006 . 16461362 . 10.1083/jcb.200510028 . 2063671 .
• Lüders J, Patel UK, Stearns T . GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. . Nat. Cell Biol. . 8 . 2 . 137–47 . 2006 . 16378099 . 10.1038/ncb1349 . 27587898 .
• Jung SY, Malovannaya A, Wei J, etal . Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. . Mol. Endocrinol. . 19 . 10 . 2451–65 . 2005 . 16051665 . 10.1210/me.2004-0476 . 24948585 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Takai S, Yoshida Y, Noda M, etal . Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization. . Hum. Genet. . 95 . 1 . 96–8 . 1995 . 7814034 . 10.1007/BF00225082 . 902030 .

Notes and References

1. Web site: Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1.