NDUFS5 explained

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.^{[1] [2] [3]}

Further reading

• Loeffen JL, Triepels RH, van den Heuvel LP, etal . cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed . Biochem. Biophys. Res. Commun. . 253 . 2 . 415–22 . 1999 . 9878551 . 10.1006/bbrc.1998.9786 .
• Loeffen J, Smeets R, Smeitink J, etal . The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients . J. Inherit. Metab. Dis. . 22 . 1 . 19–28 . 1999 . 10070614 . 10.1023/A:1005434912463 . 22326357 .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Triepels RH, Hanson BJ, van den Heuvel LP, etal . Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns . J. Biol. Chem. . 276 . 12 . 8892–7 . 2001 . 11112787 . 10.1074/jbc.M009903200 . free . 2066/185667 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Huang G, Chen Y, Lu H, Cao X . Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death . Cell Death Differ. . 14 . 2 . 327–37 . 2007 . 16826196 . 10.1038/sj.cdd.4402004 . free .

Notes and References

1. Emahazion T, Beskow A, Gyllensten U, Brookes AJ . Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain . Cytogenet Cell Genet . 82 . 1–2 . 115–9 . Nov 1998 . 9763677 . 10.1159/000015082 . 46818955 .
2. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proc Natl Acad Sci U S A . 95 . 14 . 8175–80 . Aug 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .
3. Web site: Entrez Gene: NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase).