NDUFAF8 explained

NADH:ubiquinone oxidoreductase complex assembly factor 8 is a protein that in humans is encoded by the NDUFAF8 gene.[1] This protein stabilizes NDUFAF5 during assembly of mitochondrial Complex I.

Structure

The NDUFAF8 gene is located on the q arm of chromosome 17 in position 25.3 and spans 1,987 base pairs. The gene produces a 7.756 kDa protein composed of 74 amino acids.[2] [3]

Function

The protein encoded by the NDUFAF8 gene is involved in the assembly of mitochondrial Complex I (NADH-ubiquinone oxidoreductase). This protein is required to stabilize NDUFAF5 during assembly of Complex I.[4]

Interaction

NDUFAF8 has protein-protein interactions with NDUFAF5, stabilizing it.

Notes and References

  1. Web site: Entrez Gene: NADH:ubiquinone oxidoreductase complex assembly factor 8. 2018-07-27.
  2. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P. Oct 2013. Integration of cardiac proteome biology and medicine by a specialized knowledgebase. Circulation Research. 113. 9. 1043–53. 10.1161/CIRCRESAHA.113.301151. 4076475. 23965338.
  3. Web site: Uncharacterized protein C17orf89. Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). 2018-07-27. 2018-07-28. https://web.archive.org/web/20180728035829/https://amino.heartproteome.org/web/protein/A1L188. dead.
  4. Web site: NDUFAF8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 - Homo sapiens (Human) - NDUFAF8 gene & protein]. www.uniprot.org. en. 2018-07-27.

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