NDST1 explained

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.^{[1] [2] [3]}

Further reading

• Sueyoshi T, Kakuta Y, Pedersen LC, etal . A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase. . FEBS Lett. . 433 . 3 . 211–4 . 1998 . 9744796 . 10.1016/S0014-5793(98)00913-2 . 9055616 . free .
• Aikawa J, Esko JD . Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. . J. Biol. Chem. . 274 . 5 . 2690–5 . 1999 . 9915799 . 10.1074/jbc.274.5.2690 . free .
• Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC . Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. . J. Biol. Chem. . 274 . 16 . 10673–6 . 1999 . 10196134 . 10.1074/jbc.274.16.10673 . free .
• Pikas DS, Eriksson I, Kjellén L . Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns. . Biochemistry . 39 . 15 . 4552–8 . 2000 . 10758005 . 10.1021/bi992524l .
• Mura CV, Becker MI, Orellana A, Wolff D . Immunopurification of Golgi vesicles by magnetic sorting. . J. Immunol. Methods . 260 . 1–2 . 263–71 . 2002 . 11792394 . 10.1016/S0022-1759(01)00546-4 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bengtsson J, Eriksson I, Kjellén L . Distinct effects on heparan sulfate structure by different active site mutations in NDST-1. . Biochemistry . 42 . 7 . 2110–5 . 2003 . 12590599 . 10.1021/bi026928g .
• van den Born J, Pikas DS, Pisa BJ, etal . Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. . Glycobiology . 13 . 1 . 1–10 . 2003 . 12634318 . 10.1093/glycob/cwg011 . free .
• Nakayama K, Natori Y, Sato T, etal . Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis. . J. Lab. Clin. Med. . 143 . 2 . 106–14 . 2004 . 14966466 . 10.1016/j.lab.2003.10.012 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ . Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1 . Genomics . 26 . 2 . 239–44 . Aug 1995 . 7601448 . 10.1016/0888-7543(95)80206-2 .
2. Humphries DE, Sullivan BM, Aleixo MD, Stow JL . Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network . 325 . Biochem J . (Pt 2) . 2. 351–7 . Aug 1997 . 9230113 . 1218567 . 10.1042/bj3250351.
3. Web site: Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1.