NDRG2 explained

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).^{[1] [2]}

Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation^[3]).^[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[2]

References

Further reading

• Nagase T, Ishikawa K, Kikuno R, etal . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Zhou RH, Kokame K, Tsukamoto Y, etal . Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. . Genomics . 73 . 1 . 86–97 . 2001 . 11352569 . 10.1006/geno.2000.6496 .
• Qu X, Zhai Y, Wei H, etal . Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. . Mol. Cell. Biochem. . 229 . 1–2 . 35–44 . 2002 . 11936845 . 10.1023/A:1017934810825 . 24226208 .
• Ohki T, Hongo S, Nakada N, etal . Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. . Brain Res. Dev. Brain Res. . 135 . 1–2 . 55–63 . 2002 . 11978393 . 10.1016/S0165-3806(02)00300-0 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Deng Y, Yao L, Chau L, etal . N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. . Int. J. Cancer . 106 . 3 . 342–7 . 2003 . 12845671 . 10.1002/ijc.11228 . free .
• Choi SC, Kim KD, Kim JT, etal . Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. . FEBS Lett. . 553 . 3 . 413–8 . 2003 . 14572661 . 10.1016/S0014-5793(03)01030-5 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Devroe E, Erdjument-Bromage H, Tempst P, Silver PA . Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. . J. Biol. Chem. . 279 . 23 . 24444–51 . 2004 . 15067004 . 10.1074/jbc.M401999200 . free .
• Mitchelmore C, Büchmann-Møller S, Rask L, etal . NDRG2: a novel Alzheimer's disease associated protein. . Neurobiol. Dis. . 16 . 1 . 48–58 . 2004 . 15207261 . 10.1016/j.nbd.2004.01.003 . 26992506 .
• Murray JT, Campbell DG, Morrice N, etal . Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. . Biochem. J. . 384 . Pt 3 . 477–88 . 2005 . 15461589 . 10.1042/BJ20041057 . 1134133 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Hu XL, Liu XP, Lin SX, etal . NDRG2 expression and mutation in human liver and pancreatic cancers. . World J. Gastroenterol. . 10 . 23 . 3518–21 . 2005 . 15526377 . 4576239 . 10.3748/wjg.v10.i23.3518 . free .
• Devroe E, Silver PA, Engelman A . HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. . Virology . 331 . 1 . 181–9 . 2005 . 15582665 . 10.1016/j.virol.2004.10.023 . free .
• Amente S, Napolitano G, Licciardo P, etal . Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. . FEBS Lett. . 579 . 3 . 683–9 . 2005 . 15670829 . 10.1016/j.febslet.2004.12.045 . free .
• Lusis EA, Watson MA, Chicoine MR, etal . Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. . Cancer Res. . 65 . 16 . 7121–6 . 2005 . 16103061 . 10.1158/0008-5472.CAN-05-0043 . free .

Notes and References

1. Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK . N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom . Am J Hum Genet . 67 . 1 . 47–58 . Aug 2000 . 10831399 . 1287101 . 10.1086/302978 .
2. Web site: Entrez Gene: NDRG2 NDRG family member 2.
3. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC . N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation . Int. J. Cancer . 106 . 3 . 342–7 . September 2003 . 12845671 . 10.1002/ijc.11228 . free .
4. Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A . Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma . Cancer Res. . 65 . 16 . 7121–6 . August 2005 . 16103061 . 10.1158/0008-5472.CAN-05-0043 . free .