NDFIP1 explained

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene.^[1]

Function

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].

Further reading

• Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS . Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins . J. Biol. Chem. . 283 . 47 . 32621–7 . 2008 . 18819914 . 10.1074/jbc.M804120200 . free .
• Mund T, Pelham HR . Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins . EMBO Rep. . 10 . 5 . 501–7 . 2009 . 19343052 . 2680872 . 10.1038/embor.2009.30 .
• Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS . Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons . Proc. Natl. Acad. Sci. U.S.A. . 106 . 36 . 15489–94 . 2009 . 19706893 . 2741278 . 10.1073/pnas.0904880106 . 2009PNAS..10615489H . free .
• Mund T, Pelham HR . Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 . Proc. Natl. Acad. Sci. U.S.A. . 107 . 25 . 11429–34 . 2010 . 20534535 . 2895104 . 10.1073/pnas.0911714107 . 2010PNAS..10711429M . free .
• Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS . Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes . J. Biol. Chem. . 286 . 10 . 8555–64 . 2011 . 21187286 . 3048738 . 10.1074/jbc.M110.203448 . free .
• Wang Y, Tong X, Ye X . Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation . J. Immunol. . 189 . 11 . 5304–13 . 2012 . 23087404 . 10.4049/jimmunol.1201445 . free .
• Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS . Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels . PLOS ONE . 9 . 1 . e87119 . 2014 . 24475238 . 3901732 . 10.1371/journal.pone.0087119 . 2014PLoSO...987119H . free .
• Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS . Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response . J. Biol. Chem. . 290 . 11 . 7141–50 . 2015 . 25631046 . 4358134 . 10.1074/jbc.M114.613687 . free .
• Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y . Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells . Biochem. Biophys. Res. Commun. . 465 . 4 . 851–6 . 2015 . 26319551 . 10.1016/j.bbrc.2015.08.099 .

Notes and References

1. Web site: Entrez Gene: Nedd4 family interacting protein 1. 2017-10-18.