| State: | NC |
| Type: | NC |
| Route: | 45 |
| Map: | NC 45 map.svg |
| Map Notes: | Route of NC 45 highlighted in red; Swan Quarter-Ocracoke Ferry in dashed red |
| Length Mi: | 121.7 |
| Length Round: | 1 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | in Ocracoke |
| Terminus B: | near Winton |
| Junction: | in Swan Quarter near Merry Hill |
| Counties: | Hyde, Beaufort, Washington, Bertie, Hertford |
| Established: | 1940 |
| Tourist: | Pamlico Scenic Byway |
| Previous Type: | NC |
| Previous Route: | 43 |
| Next Type: | NC |
| Next Route: | 46 |
North Carolina Highway 45 (NC 45) is a primary state highway in the U.S. state of North Carolina. The highway traverses north–south, from Ocracoke to Winton.
NC 45 starts at the ferry terminal at Ocracoke, connecting with NC 12, it traverses across the Pamlico Sound along the Swan Quarter-Ocracoke Ferry. At Swan Quarter, it continues at a northwesterly direction; merging with several highways along the way, including US 264, NC 99, NC 32, US 64, NC 308, and NC 461. North of Plymouth, it parallels west of the Chowan River before reaching its northern terminus at US 13/US 158, near Winton.
On May 1, 2013, NC 45 was extended south from Swan Quarter to its current southern terminus in Ocracoke, crossing over the Pamlico Sound along the Swan Quarter-Ocracoke Ferry. NC 45 does not traverse beyond the ferry terminal.[1]