| State: | NC |
| Type: | NC |
| Route: | 22 |
| Length Mi: | 59.3 |
| Map: | NC 22 map.svg |
| Map Notes: | Route of NC 22 highlighted in red |
| Direction B: | North |
| Direction A: | South |
| Terminus B: | in Climax |
| Junction: | in Carthage in Ramseur |
| Terminus A: | in Southern Pines |
| Counties: | Moore, Chatham, Randolph, Guilford |
| Established: | 1934 |
| Previous Type: | US |
| Previous Route: | 21 |
| Next Type: | US |
| Next Route: | 23 |
North Carolina Highway 22 (NC 22) is a North Carolina state highway that runs in the central-north region of the state. It runs between Southern Pines and Climax. The route is signed north - south, and is 59miles in length.
NC 22 begins at a roundabout at the junction with NC 2, just shy of the interchange at US 1 in Southern Pines. It heads north along Central Drive and then runs independently after the roundabout at Airport Road. NC 22 then runs concurrent with US 15/US 501 for about 1miles before entering Carthage from the south. At the intersection with Monroe Street in Carthage, NC 22 joins NC 24/NC 27 and heads west sharing its concurrency with NC 24 and NC 27 for about 5miles. NC 22 then heads north again, passing through High Falls before it meets NC 42. From there, NC 22 becomes concurrent with NC 42 heading into Coleridge and intersects the western terminus of NC 902 south of Bennett. After entering Coleridge, NC 22 splits from NC 42 and heads north into Ramseur. It meets US 64 and runs concurrent with it along Jordan Road before heading west through Franklinville. The route continues north until it reaches its northern terminus at the junction of NC 62 in Climax.