NCR1 explained

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene.^{[1] [2]} NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94.^[3]

Further reading

• Biassoni R . Human natural killer cell receptors: insights into their molecular function and structure . J. Cell. Mol. Med. . 7 . 4 . 376–87 . 2004 . 14754506 . 10.1111/j.1582-4934.2003.tb00240.x . vanc. Cantoni C . Marras D . 3 . Giron-Michel . J. . Falco . Michela . Moretta . L. . Dimasi . N. . 6740120 .
• Sivori S . p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation . J. Exp. Med. . 186 . 7 . 1129–36 . 1997 . 9314561 . 10.1084/jem.186.7.1129 . 2211712 . vanc. Vitale M . Morelli L . 3 . Sanseverino . L . Augugliaro . R . Bottino . C . Moretta . L . Moretta . A .
• Vitale M . NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis . J. Exp. Med. . 187 . 12 . 2065–72 . 1998 . 9625766 . 10.1084/jem.187.12.2065 . 2212362 . vanc. Bottino C . Sivori S . 3 . Sanseverino . L . Castriconi . R . Marcenaro . E . Augugliaro . R . Moretta . L . Moretta . A .
• Cantoni C . NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily . J. Exp. Med. . 189 . 5 . 787–96 . 1999 . 10049942 . 10.1084/jem.189.5.787 . 2192947 . vanc. Bottino C . Vitale M . 3 . Pessino . A . Augugliaro . R . Malaspina . A . Parolini . S . Moretta . L . Moretta . A .
• Vankayalapati R . The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium . J. Immunol. . 168 . 7 . 3451–7 . 2002 . 11907104 . 10.4049/jimmunol.168.7.3451. vanc. Wizel B . Weis SE . 3 . Safi . H . Lakey . DL . Mandelboim . O . Samten . B . Porgador . A . Barnes . PF . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Augugliaro R . Selective cross-talk among natural cytotoxicity receptors in human natural killer cells . Eur. J. Immunol. . 33 . 5 . 1235–41 . 2003 . 12731048 . 10.1002/eji.200323896 . vanc. Parolini S . Castriconi R . 3 . Marcenaro . Emanuela . Cantoni . Claudia . Nanni . Marina . Moretta . Lorenzo . Moretta . Alessandro . Bottino . Cristina . 10724743 . free .
• Ponassi M . Structure of the human NK cell triggering receptor NKp46 ectodomain . Biochem. Biophys. Res. Commun. . 309 . 2 . 317–23 . 2003 . 12951052 . 10.1016/j.bbrc.2003.08.007 . vanc. Cantoni C . Biassoni R . 3 . Conte . Romana . Spallarossa . Andrea . Pesce . Alessandra . Moretta . Alessandro . Moretta . Lorenzo . Bolognesi . Martino .
• Foster CE, Colonna M, Sun PD . Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors . J. Biol. Chem. . 278 . 46 . 46081–6 . 2003 . 12960161 . 10.1074/jbc.M308491200 . free .
• Arnon TI . The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46 . Blood . 103 . 2 . 664–72 . 2004 . 14504081 . 10.1182/blood-2003-05-1716 . vanc. Achdout H . Lieberman N . 3 . Gazit . R . Gonen-Gross . T . Katz . G . Bar-Ilan . A . Bloushtain . N . Lev . M . free .
• Marcenaro E . CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity . Eur. J. Immunol. . 33 . 12 . 3367–76 . 2004 . 14635045 . 10.1002/eji.200324425 . vanc. Augugliaro R . Falco M . 3 . Castriconi . Roberta . Parolini . Silvia . Sivori . Simona . Romeo . Elisa . Millo . Romano . Moretta . Lorenzo . 40345630 . free .
• Carbone E . HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells . Blood . 105 . 1 . 251–8 . 2005 . 15328155 . 10.1182/blood-2004-04-1422 . vanc. Neri P . Mesuraca M . 3 . Fulciniti . MT . Otsuki . T . Pende . D . Groh . V . Spies . T . Pollio . G . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Mavoungou E, Bouyou-Akotet MK, Kremsner PG . Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30) . Clin. Exp. Immunol. . 139 . 2 . 287–96 . 2005 . 15654827 . 10.1111/j.1365-2249.2004.02686.x . 1809301 .
• Nowbakht P . Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias . Blood . 105 . 9 . 3615–22 . 2005 . 15657183 . 10.1182/blood-2004-07-2585 . vanc. Ionescu MC . Rohner A . 3 . Kalberer . CP . Rossy . E . Mori . L . Cosman . D . De Libero . G . Wodnar-Filipowicz . A . free .
• Poggi A . Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors . J. Immunol. . 174 . 5 . 2653–60 . 2005 . 15728472 . 10.4049/jimmunol.174.5.2653. vanc. Massaro AM . Negrini S . 3 . Contini . P . Zocchi . MR . free.
• Zilka A . Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46 . Biochemistry . 44 . 44 . 14477–85 . 2006 . 16262248 . 10.1021/bi051241s . vanc. Landau G . Hershkovitz O . 3 . Bloushtain . Noga . Bar-Ilan . Ahuva . Benchetrit . Fabrice . Fima . Eyal . Van Kuppevelt . Toin H. . Gallagher . John T. .
• Hermann E . Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells . Pediatr. Res. . 60 . 1 . 38–43 . 2006 . 16690951 . 10.1203/01.pdr.0000220335.05588.ea . vanc. Alonso-Vega C . Berthe A . 3 . Truyens . Carine . Flores . Amilcar . Cordova . Marisol . Moretta . Lorenzo . Torrico . Faustino . Braud . Veronique . free .

Notes and References

1. Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A . Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity . J Exp Med . 188 . 5 . 953–60 . Sep 1998 . 9730896 . 3207313. 10.1084/jem.188.5.953 .
2. Web site: Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1.
3. Web site: NCR1 natural cytotoxicity triggering receptor 1 [Homo sapiens (human)] - Gene - NCBI.