NCOA5 explained

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.^[1]

Function

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.^[2]

Further reading

• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Tao WA, Wollscheid B, O'Brien R, etal . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry . Nat. Methods . 2 . 8 . 591–8 . 2005 . 16094384 . 10.1038/nmeth776 . 20475874 .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Jiang C, Ito M, Piening V, etal . TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription . J. Biol. Chem. . 279 . 26 . 27781–9 . 2004 . 15073177 . 10.1074/jbc.M401809200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Sauvé F, McBroom LD, Gallant J, etal . CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant . Mol. Cell. Biol. . 21 . 1 . 343–53 . 2001 . 11113208 . 10.1128/MCB.21.1.343-353.2001 . 88807 .
• Nagase T, Kikuno R, Nakayama M, etal . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 4 . 273–81 . 2001 . 10997877 . 10.1093/dnares/7.4.271. free .

Notes and References

1. Sauvé F, McBroom LD, Gallant J, Moraitis AN, Labrie F, Giguère V . CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant . Molecular and Cellular Biology . 21 . 1 . 343–53 . January 2001 . 11113208 . 88807 . 10.1128/MCB.21.1.343-353.2001 .
2. Web site: Entrez Gene: NCOA5 nuclear receptor coactivator 5.