NCKAP1 explained

Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.^{[1] [2] [3] [4]}

Interactions

NCKAP1 has been shown to interact with RAC1^[5] and ABI1.^[6]

Further reading

• Kitamura T, Kitamura Y, Yonezawa K, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M . Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck . Biochemical and Biophysical Research Communications . 219 . 2 . 509–14 . Feb 1996 . 8605018 . 10.1006/bbrc.1996.0264 . 20.500.14094/D1001555 . free .
• Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K . p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase . The Journal of Biological Chemistry . 273 . 1 . 291–5 . Jan 1998 . 9417078 . 10.1074/jbc.273.1.291 . free .
• Witke W, Podtelejnikov AV, Di Nardo A, Sutherland JD, Gurniak CB, Dotti C, Mann M . In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly . The EMBO Journal . 17 . 4 . 967–76 . Feb 1998 . 9463375 . 1170446 . 10.1093/emboj/17.4.967 .
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–9 . Feb 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
• Yamamoto A, Suzuki T, Sakaki Y . Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease . Gene . 271 . 2 . 159–69 . Jun 2001 . 11418237 . 10.1016/S0378-1119(01)00521-2 .
• Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P . Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton . The Journal of Biological Chemistry . 278 . 49 . 49031–43 . Dec 2003 . 14506234 . 10.1074/jbc.M308104200 . free .
• Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M . Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling . Molecular and Cellular Biology . 23 . 21 . 7780–93 . Nov 2003 . 14560022 . 207563 . 10.1128/MCB.23.21.7780-7793.2003 .
• Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G . Abi1 is essential for the formation and activation of a WAVE2 signalling complex . Nature Cell Biology . 6 . 4 . 319–27 . Apr 2004 . 15048123 . 10.1038/ncb1105 . 22767022 .
• Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M . CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion . European Journal of Immunology . 34 . 4 . 1217–27 . Apr 2004 . 15048733 . 10.1002/eji.200324726 . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Chen W, Tang Z, Fortina P, Patel P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ . Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways . Virology . 334 . 1 . 59–73 . Mar 2005 . 15749123 . 10.1016/j.virol.2005.01.014 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y . Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease . Genomics . 63 . 2 . 246–54 . Jan 2000 . 10673335 . 10.1006/geno.1999.6053 .
2. Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW . Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck . Nature . 418 . 6899 . 790–3 . Aug 2002 . 12181570 . 10.1038/nature00859 . 2002Natur.418..790E . 4350733 .
3. Matuoka K, Miki H, Takahashi K, Takenawa T . A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs . Biochemical and Biophysical Research Communications . 239 . 2 . 488–92 . Oct 1997 . 9344857 . 10.1006/bbrc.1997.7492 .
4. Web site: Entrez Gene: NCKAP1 NCK-associated protein 1.
5. Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada SI, Sakaue M, Ogawa W, Kasuga M . Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac . The Biochemical Journal . 322 . Pt 3 . 873–8 . Mar 1997 . 9148763 . 1218269 . 10.1042/bj3220873.
6. Yamamoto A, Suzuki T, Sakaki Y . Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease . Gene . 271 . 2 . 159–69 . Jun 2001 . 11418237 . 10.1016/S0378-1119(01)00521-2 .