NCAPG2 explained

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.^{[1] [2]} CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis^[3]

Clinical importance

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.^[4]

Further reading

• Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD . More than blood, a novel gene required for mammalian postimplantation development . Molecular and Cellular Biology . 24 . 3 . 1168–73 . February 2004 . 14729962 . 321451 . 10.1128/MCB.24.3.1168-1173.2004 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . April 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .

Notes and References

1. Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T . Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells . Cell . 115 . 1 . 109–21 . October 2003 . 14532007 . 10.1016/S0092-8674(03)00724-4 . 18811084 . free .
2. Web site: Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2.
3. Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT . The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores . Nature Communications . 5 . 4588 . August 2014 . 25109385 . 10.1038/ncomms5588 . 2014NatCo...5.4588K . free .
4. Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N . Task Force for Neonatal Genomics . Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies . American Journal of Human Genetics . 104 . 1 . 94–111 . January 2019 . 30609410 . 10.1016/j.ajhg.2018.11.017 . 6323578 .