NBR1 explained

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.^{[1] [2]}

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.^[2] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.^[3]

Interactions

NBR1 has been shown to interact with FEZ1.^[4]

Further reading

• Miki Y . A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 . Science . 266 . 5182 . 66–71 . 1994 . 7545954 . 10.1126/science.7545954 . vanc. Swensen J . Shattuck-Eidens D . 3 . Futreal . P. . Harshman . K . Tavtigian . S . Liu . Q . Cochran . C . Bennett . L. . 1994Sci...266...66M. free .
• Harshman K . Comparison of the positional cloning methods used to isolate the BRCA1 gene . Hum. Mol. Genet. . 4 . 8 . 1259–1266 . 1995 . 7581362 . 10.1093/hmg/4.8.1259 . vanc. Bell R . Rosenthal J . 3 . Katcher . Harold . Mlkl . Yoshio . Swenson . Jeff . Gholami . Zahra . Frye . Cheryl . Ding . Wei .
• Nomura N . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 1 . 5 . 223–229 . 1995 . 7584044 . 10.1093/dnares/1.5.223 . vanc. Nagase T . Miyajima N . 3 . Sazuka . T . Tanaka . A . Sato . S . Seki . N . Kawarabayasi . Y . Ishikawa . K . free .
• Brown MA . Regulation of BRCA1 . Nature . 372 . 6508 . 733 . 1995 . 7997258 . 10.1038/372733a0 . vanc. Nicolai H . Xu CF . 3 . Griffiths . Beatrice L. . Jones . Karen A. . Solomon . Ellen . Hosking . Louise . Trowsdale . John . Black . Donald M. . 1994Natur.372..733B. 40825012 . free .
• Brown MA . The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21 . Oncogene . 12 . 12 . 2507–13 . 1996 . 8700509 . vanc. Xu CF . Nicolai H . 3 . Griffiths . B . Chambers . JA . Black . D . Solomon . E .
• Dimitrov S, Brennerova M, Forejt J . Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes . Gene . 262 . 1–2 . 89–98 . 2001 . 11179671 . 10.1016/S0378-1119(00)00549-7 .
• Whitehouse C . NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube . Eur. J. Biochem. . 269 . 2 . 538–545 . 2002 . 11856312 . 10.1046/j.0014-2956.2001.02681.x . vanc. Chambers J . Howe K . 3 . Cobourne . Martyn . Sharpe . Paul . Solomon . Ellen . free .
• Wistow G . Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium . Mol. Vis. . 8 . 185–95 . 2002 . 12107412 . vanc. Bernstein SL . Ray S . 3 . Wyatt . MK . Behal . A . Touchman . JW . Bouffard . G . Smith . D . Peterson . K .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Lamark T . Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins . J. Biol. Chem. . 278 . 36 . 34568–34581 . 2003 . 12813044 . 10.1074/jbc.M303221200 . vanc. Perander M . Outzen H . 3 . Kristiansen . K . Øvervatn . A . Michaelsen . E . Bjørkøy . G . Johansen . T . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lange S . The kinase domain of titin controls muscle gene expression and protein turnover . Science . 308 . 5728 . 1599–1603 . 2005 . 15802564 . 10.1126/science.1110463 . vanc. Xiang F . Yakovenko A . 3 . Vihola . A . Hackman . P . Rostkova . E . Kristensen . J . Brandmeier . B . Franzen . G . 2005Sci...308.1599L. 10.1.1.383.9888 . 2809403 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R. 4427026 .

Notes and References

1. Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, ((Bast RC Jr)), Solomon E . A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1 . Hum Mol Genet . 3 . 4 . 589–594 . Sep 1994 . 8069304 . 10.1093/hmg/3.4.589 .
2. Web site: Entrez Gene: NBR1 neighbor of BRCA1 gene 1.
3. Kirkin. Vladimir. A Role for Ubiquitin in Selective Autophagy. Molecular Cell. 2009. 34. 3. 10.1016/j.molcel.2009.04.026. 19450525. 259–269. free.
4. Whitehouse . Caroline . Chambers Julie . Howe Kathy . Cobourne Martyn . Sharpe Paul . Solomon Ellen . Jan 2002 . NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube . Eur. J. Biochem. . 269 . 2 . 538–545 . 0014-2956. 11856312 . 10.1046/j.0014-2956.2001.02681.x . free .