25E-NBOH explained

25E-NBOH (2C-E-NBOH, NBOH-2C-E) is a derivative of the phenethylamine derived hallucinogen 2C-E. It was first developed by Martin Hansen at the University of Copenhagen in 2010 as a brain imaging agent,^[1] but has subsequently been sold as a designer drug, first being identified in Brazil in 2018 on seized blotter paper,^{[2] [3] [4]} as well as in Slovenia ^[5] and France.^[6] It acts as a potent serotonin receptor agonist with similar affinity to better-known compounds such as 25I-NBOMe at 5-HT_2A and 5-HT_2C receptors.^[7]

Legal status

United Kingdom

See also

• 4-EA-NBOMe
• DOET
• 2C-TFE
• 2C-E-FLY

Notes and References

1. Hansen M . Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain. . Ph.D. . University of Copenhagen . 2010-12-16 . 10.13140/RG.2.2.33671.14245.
2. Machado Y, Neto JC, Lordeiro RA, Silva MF, Piccin E . Profile of new psychoactive substances (NPS) and other synthetic drugs in seized materials analysed in a Brazilian forensic laboratory. . Forensic Toxicology . January 2019 . 37 . 1 . 265–71 . 10.1007/s11419-018-0456-3 . 53812909 .
3. Machado Y, Neto JC, Lordeiro RA, Alves RB, Piccin E . Identification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH. . Forensic Toxicology . January 2020 . 38 . 1 . 203–15 . 10.1007/s11419-019-00509-7 . 209672508 . free .
4. Rodrigues de Morais D, Francisco da Cunha K, Betoni Rodrigues T, Lanaro R, de Melo Barbosa L, Jardim Zacca J, Nogueira Eberlin M, Costa JL . Triple quadrupole-mass spectrometry protocols for the analysis of NBOMes and NBOHs in blotter papers . Forensic Science International . 309 . 110184 . April 2020 . 32086005 . 10.1016/j.forsciint.2020.110184 . 211246833 .
5. https://www.policija.si/apps/nfl_response_web/0_Analytical_Reports_final/25E-NBOH-ID-1901-18_report.pdf Analytical Report. 25E-NBOH. Nacionalni Forenzični Laboratorij, Slovenia, 24 January 2018
6. Pelletier R, Gicquel T, Carvelli J, Balaz P, Pelissier-Alicot AL, Morel I, Bottinelli C, Solas C, Le Daré B, Fabresse N . Severe 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review . International Journal of Legal Medicine . 138 . 3 . 815–822 . May 2024 . 38117418 . 10.1007/s00414-023-03151-6 .
7. Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL . Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists . ACS Chemical Neuroscience . 5 . 3 . 243–9 . March 2014 . 24397362 . 3963123 . 10.1021/cn400216u .