NAT8 explained

N-acetyltransferase 8 is a protein that in humans is encoded by the NAT8 gene.^[1]

Clinical relevance

Mutations in the NAT8 gene have been associated with chronic kidney disease.^[2]

Further reading

• Ko MH, Puglielli L . Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. . J. Biol. Chem. . 284 . 4 . 2482–92 . 2009 . 19011241 . 10.1074/jbc.M804901200 . 2629114. free .
• Ozaki K, Fujiwara T, Nakamura Y, Takahashi E . Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases. . J. Hum. Genet. . 43 . 4 . 255–8 . 1998 . 9852678 . 10.1007/s100380050084 . free .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Veiga-da-Cunha M, Tyteca D, Stroobant V, etal . Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. . J. Biol. Chem. . 285 . 24 . 18888–98 . 2010 . 20392701 . 10.1074/jbc.M110.110924 . 2881811. free .
• Ariyannur PS, Moffett JR, Manickam P, etal . Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. . Brain Res. . 1335 . 1–13 . 2010 . 20385109 . 10.1016/j.brainres.2010.04.008 . 206324237 .
• Popsueva AE, Luchinskaya NN, Ludwig AV, etal . Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. . Dev. Biol. . 234 . 2 . 483–96 . 2001 . 11397015 . 10.1006/dbio.2001.0261 . free .
• Juhanson P, Kepp K, Org E, etal . N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study. . BMC Med. Genet. . 9 . 25 . 2008 . 18402670 . 10.1186/1471-2350-9-25 . 2330028 . free .
• Veréb J, Démant F, Pavkovceková O, Tischler V . [Agenesis and aplasia of the kidney in children in the x-ray diagnostic picture]. . Cesk Pediatr . 30 . 3 . 94–7 . 1975 . 1139715 .
• Köttgen A, Pattaro C, Böger CA, etal . New loci associated with kidney function and chronic kidney disease. . Nat. Genet. . 42 . 5 . 376–84 . 2010 . 20383146 . 10.1038/ng.568 . 2997674.
• Chambers JC, Zhang W, Lord GM, etal . Genetic loci influencing kidney function and chronic kidney disease. . Nat. Genet. . 42 . 5 . 373–5 . 2010 . 20383145 . 10.1038/ng.566 . 3748585 .

Notes and References

1. Web site: Entrez Gene: N-acetyltransferase 8 (GCN5-related.
2. Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C . Human metabolic individuality in biomedical and pharmaceutical research . Nature . 477 . 7362 . 54–60 . September 2011 . 21886157 . 10.1038/nature10354 . 3832838 . 2011Natur.477...54S .