NAPG explained

Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.^{[1] [2]}

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.^[2]

Further reading

• Wilson DW, Whiteheart SW, Wiedmann M, etal . A multisubunit particle implicated in membrane fusion. . J. Cell Biol. . 117 . 3 . 531–8 . 1992 . 1315316 . 10.1083/jcb.117.3.531 . 2289450 .
• Whiteheart SW, Brunner M, Wilson DW, etal . Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes. . J. Biol. Chem. . 267 . 17 . 12239–43 . 1992 . 10.1016/S0021-9258(19)49830-X . 1601890 . free .
• Whiteheart SW, Griff IC, Brunner M, etal . SNAP family of NSF attachment proteins includes a brain-specific isoform. . Nature . 362 . 6418 . 353–5 . 1993 . 8455721 . 10.1038/362353a0 . 1993Natur.362..353W . 4341471 .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Mastick CC, Falick AL . Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes. . Endocrinology . 138 . 6 . 2391–7 . 1997 . 9165027 . 10.1210/endo.138.6.5166 . free .
• Subramaniam VN, Loh E, Horstmann H, etal . Preferential association of syntaxin 8 with the early endosome. . J. Cell Sci. . 113 . 6. 997–1008 . 2000 . 10.1242/jcs.113.6.997 . 10683148 .
• Chen D, Xu W, He P, etal . Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. . J. Biol. Chem. . 276 . 16 . 13127–35 . 2001 . 11278501 . 10.1074/jbc.M009424200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tani K, Shibata M, Kawase K, etal . Mapping of functional domains of gamma-SNAP. . J. Biol. Chem. . 278 . 15 . 13531–8 . 2003 . 12554740 . 10.1074/jbc.M213205200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW . Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery . Blood . 90 . 4 . 1490–500 . Sep 1997 . 9269766 . 10.1182/blood.V90.4.1490. free .
2. Web site: Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma.