N-acetyl-D-glucosamine kinase explained

N-acetyl-D-glucosamine kinase is an enzyme that in humans is encoded by the NAGK gene.^{[1] [2]}

Function

N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.[supplied by OMIM]^[2]

Interactions

NAGK has been shown to interact with STK16^[3] and LNX1.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Weidanz JA, Campbell P, Moore D, DeLucas LJ, Rodén L, Thompson JN, Vezza AC . N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum . British Journal of Haematology . 95 . 4 . 645–53 . Dec 1996 . 8982040 . 10.1046/j.1365-2141.1996.d01-1955.x . 40747266 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lowes W, Walker M, Alberti KG, Agius L . Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis . Biochimica et Biophysica Acta (BBA) - General Subjects . 1379 . 1 . 134–42 . Jan 1998 . 9468341 . 10.1016/s0304-4165(97)00092-5 .
• Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A . Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling . The Journal of Biological Chemistry . 277 . 8 . 6333–43 . Feb 2002 . 11741987 . 10.1074/jbc.M105766200 . free .
• Maguire PB, Wynne KJ, Harney DF, O'Donoghue NM, Stephens G, Fitzgerald DJ . Identification of the phosphotyrosine proteome from thrombin activated platelets . Proteomics . 2 . 6 . 642–8 . Jun 2002 . 12112843 . 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I . 22665513 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Sparks SE, Ciccone C, Lalor M, Orvisky E, Klootwijk R, Savelkoul PJ, Dalakas MC, Krasnewich DM, Gahl WA, Huizing M . Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy . Glycobiology . 15 . 11 . 1102–10 . Nov 2005 . 15987957 . 10.1093/glycob/cwi100 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Weihofen WA, Berger M, Chen H, Saenger W, Hinderlich S . Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation . Journal of Molecular Biology . 364 . 3 . 388–99 . Dec 2006 . 17010375 . 10.1016/j.jmb.2006.08.085 .

Notes and References

1. Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W . Molecular cloning and characterization of murine and human N-acetylglucosamine kinase . European Journal of Biochemistry . 267 . 11 . 3301–8 . Jun 2000 . 10824116 . 10.1046/j.1432-1327.2000.01360.x . free .
2. Web site: Entrez Gene: NAGK N-acetylglucosamine kinase.
3. Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A . Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling . The Journal of Biological Chemistry . 277 . 8 . 6333–43 . Feb 2002 . 11741987 . 10.1074/jbc.M105766200 . free .
4. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .