NADP-retinol dehydrogenase explained

NADP-retinol dehydrogenase
Ec Number:	1.1.1.300

NADP-retinol dehydrogenase (all-trans retinal reductase, all-trans-retinol dehydrogenase, NADP(H)-dependent retinol dehydrogenase/reductase, RDH11, RDH12, RDH13, RDH14, retinol dehydrogenase 12, retinol dehydrogenase 14, retinol dehydrogenase (NADP⁺), RalR1, PSDR1) is an enzyme with systematic name retinol:NADP⁺ oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

retinol + NADP⁺

\rightleftharpoons retinal + NADPH + H⁺

This enzyme has greater catalytic efficiency in the reductive direction.

Notes and References

1. Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY . Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids . Biochemistry . 44 . 18 . 7035–47 . May 2005 . 15865448 . 2679700 . 10.1021/bi050226k .
2. Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY . Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity . The FEBS Journal . 275 . 1 . 138–47 . January 2008 . 18039331 . 2573044 . 10.1111/j.1742-4658.2007.06184.x .
3. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K . Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal . The Journal of Biological Chemistry . 273 . 34 . 21790–9 . August 1998 . 9705317 . 10.1074/jbc.273.34.21790 . free .
4. Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS . Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1) . The Journal of Biological Chemistry . 277 . 32 . 28909–15 . August 2002 . 12036956 . 10.1074/jbc.M202588200 . free .