NADH dehydrogenase explained

NADH dehydrogenase
Altnames:	cytochrome c reductase, type 1 dehydrogenase, beta-NADH dehydrogenase dinucleotide, diaphorase, dihydrocodehydrogenase I dehydrogenase, dihydronicotinamide adenine dinucleotide dehydrogenase, diphosphopyridine diaphorase, DPNH diaphorase, NADH diaphorase, NADH hydrogenase, NADH oxidoreductase, NADH-menadione oxidoreductase, reduced diphosphopyridine nucleotide diaphorase
Ec Number:	7.1.1.2
Cas Number:	9079-67-8

NADH dehydrogenase is an enzyme that converts nicotinamide adenine dinucleotide (NAD) from its reduced form (NADH) to its oxidized form (NAD⁺). Members of the NADH dehydrogenase family and analogues are commonly systematically named using the format NADH:acceptor oxidoreductase.^{[1] [2] [3] [4]} The chemical reaction these enzymes catalyze is generally represented with the following equation:

NADH + H⁺ + acceptor NAD⁺ + reduced acceptor

NADH dehydrogenase is a flavoprotein that contains iron-sulfur centers.

NADH dehydrogenase is used in the electron transport chain for generation of ATP.

The EC term NADH dehydrogenase (quinone) (EC 1.6.5.11) is defined for NADH dehydrogenases that use a quinone (excluding ubiquinone) as the acceptor. The EC term NADH dehydrogenase (ubiquinone) (EC 7.1.1.2) is defined for those with ubiquinone as the acceptor.

Notes and References

1. Adachi K, Okuyama T . Study on the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes. I. Crystallization and properties of the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes . Biochimica et Biophysica Acta (BBA) - Enzymology . 268 . 3 . 629–37 . June 1972 . 4402556 . 10.1016/0005-2744(72)90266-5 .
2. Book: The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system . The Enzymes of Biological Membranes . Hatefi, Y. . Ragan, C.I. . Galante, Y.M. . 1985 . 4 . 1–70 . Martonosi, A. . 2nd . Plenum Press . New York .
3. Hochstein LI, Dalton BP . Studies of a halophilic NADH dehydrogenase. I. Purification and properties of the enzyme . Biochimica et Biophysica Acta (BBA) - Enzymology . 302 . 2 . 216–28 . April 1973 . 4144655 . 10.1016/0005-2744(73)90150-2 .
4. Kaniuga Z . The transformation of mitochondrial NADH dehydrogenase into NADH: Cytochrome c oxidoreductase . Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects . 73 . 550–64 . August 1963 . 4 . 14074130 . 10.1016/0926-6569(63)90175-5 .