NAD(P)H-hydrate epimerase explained

NAD(P)H-hydrate epimerase
Ec Number:	5.1.99.6

NAD(P)H-hydrate epimerase (NAD(P)HX epimerase) is an enzyme with systematic name (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase.^[1] This enzyme catalyses the following chemical reaction

(1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

\rightleftharpoons (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

\rightleftharpoons (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.

Notes and References

1. Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL . Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair . The Journal of Biological Chemistry . 286 . 48 . 41246–52 . December 2011 . 21994945 . 3308837 . 10.1074/jbc.c111.310847 . free .