NAD+-diphthamide ADP-ribosyltransferase | |
Ec Number: | 2.4.2.36 |
Cas Number: | 52933-21-8 |
Go Code: | 0047286 |
In enzymology, a NAD+-diphthamide ADP-ribosyltransferase is an enzyme that catalyzes the chemical reaction
NAD+ + peptide diphthamide
\rightleftharpoons
Thus, the two substrates of this enzyme are NAD+ and peptide diphthamide, whereas its two products are nicotinamide and peptide N-(ADP-D-ribosyl)diphthamide.
This enzyme belongs to the family of glycosyltransferases, to be specific, the pentosyltransferases. The systematic name of this enzyme class is NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase. Other names in common use include ADP-ribosyltransferase, mono(ADPribosyl)transferase, and NAD-diphthamide ADP-ribosyltransferase.
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,, and .
The extracellular ADP-ribosyl-transferase ART2 is expressed only on T cells.[1] T cell activation of P2X7 receptors can activate the T cells or cause T cell differentiation, can affect T cell migration or (at high extracellular levels of NAD+) can induce cell death by ART2.