N-sulfoglucosamine-3-sulfatase explained

N-sulfoglucosamine-3-sulfatase
Ec Number:	3.1.6.15

The enzyme N-sulfoglucosamine-3-sulfatase (EC 3.1.6.15}) catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.^{[1] [2]}

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name is N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradation of glycan structures.

Notes and References

1. Bruce JS, McLean MW, Long WF, Williamson FB . 1985 . Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate . Eur. J. Biochem. . 148 . 359–65 . 3987694 . 10.1111/j.1432-1033.1985.tb08847.x . 2 .
2. Leder IG . 1980 . A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate . Biochem. Biophys. Res. Commun. . 94 . 1183–9 . 7396957 . 10.1016/0006-291X(80)90544-6 . 4 .