N-nucleotide explained

N-nucleotides, or nontemplated nucleotides are believed to exist only to create diversity at V(D)J junctions (see V(D)J recombination) during lymphocyte development.[1] The addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase (TdT)

Notes and References

  1. 390357 . 15047854 . 10.1093/nar/gkh502 . 32 . Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks . 2004 . Nucleic Acids Res. . 1866–73 . Sandor . Z . Calicchio . ML . Sargent . RG . Roth . DB . Wilson . JH. 6 .

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