Glycylpeptide N-tetradecanoyltransferase 1 explained

Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an enzyme that in humans is encoded by the NMT1 gene.^{[1] [2]} It belongs to the protein N-terminal methyltransferase and glycylpeptide N-tetradecanoyltransferase family of enzymes.

Further reading

• Rajala RV, Datla RS, Moyana TN, etal . N-myristoyltransferase. . Mol. Cell. Biochem. . 204 . 1–2 . 135–55 . 2000 . 10718634 . 10.1023/A:1007012622030 . 264010084 .
• Geyer M, Fackler OT, Peterlin BM . Structure--function relationships in HIV-1 Nef . EMBO Rep. . 2 . 7 . 580–5 . 2001 . 11463741 . 10.1093/embo-reports/kve141 . 1083955 .
• Wice BM, Gordon JI . A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin . J. Cell Biol. . 116 . 2 . 405–22 . 1992 . 1530946 . 10.1083/jcb.116.2.405 . 2289284 .
• Mumby SM, Heukeroth RO, Gordon JI, Gilman AG . G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells . Proc. Natl. Acad. Sci. U.S.A. . 87 . 2 . 728–32 . 1990 . 2153964 . 10.1073/pnas.87.2.728 . 53339 . 1990PNAS...87..728M . free .
• Pal R, Reitz MS, Tschachler E, etal . Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly . AIDS Res. Hum. Retroviruses . 6 . 6 . 721–30 . 1990 . 2194551 . 10.1089/aid.1990.6.721 .
• Bryant M, Ratner L . Myristoylation-dependent replication and assembly of human immunodeficiency virus 1 . Proc. Natl. Acad. Sci. U.S.A. . 87 . 2 . 523–7 . 1990 . 2405382 . 10.1073/pnas.87.2.523 . 53297 . 1990PNAS...87..523B . free .
• Tashiro A, Shoji S, Kubota Y . Antimyristoylation of the gag proteins in the human immunodeficiency virus-infected cells with N-myristoyl glycinal diethylacetal resulted in inhibition of virus production . Biochem. Biophys. Res. Commun. . 165 . 3 . 1145–54 . 1990 . 2692561 . 10.1016/0006-291X(89)92722-8 .
• Goddard C, Aquino A, Glazer RI, Felsted RL . Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein . Eur. J. Biochem. . 182 . 2 . 323–6 . 1989 . 2737204 . 10.1111/j.1432-1033.1989.tb14833.x .
• Göttlinger HG, Sodroski JG, Haseltine WA . Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 86 . 15 . 5781–5 . 1989 . 2788277 . 10.1073/pnas.86.15.5781 . 297714 . 1989PNAS...86.5781G . free .
• Schultz AM, Henderson LE, Oroszlan S, etal . Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein . Science . 227 . 4685 . 427–9 . 1985 . 3917576 . 10.1126/science.3917576 . 1985Sci...227..427S .
• Liu J, Sessa WC . Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase . J. Biol. Chem. . 269 . 16 . 11691–4 . 1994 . 10.1016/S0021-9258(17)32626-1 . 7512951 . free .
• Lee PP, Linial ML . Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal . J. Virol. . 68 . 10 . 6644–54 . 1994 . 7521919 . 10.1128/JVI.68.10.6644-6654.1994. 237085 .
• Sigal CT, Zhou W, Buser CA, etal . Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids . Proc. Natl. Acad. Sci. U.S.A. . 91 . 25 . 12253–7 . 1995 . 7527558 . 10.1073/pnas.91.25.12253 . 45415 . free .
• Zhou W, Parent LJ, Wills JW, Resh MD . Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids . J. Virol. . 68 . 4 . 2556–69 . 1994 . 8139035 . 10.1128/JVI.68.4.2556-2569.1994. 236733 .
• Kobayashi M, Takamatsu K, Saitoh S, Noguchi T . Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties . J. Biol. Chem. . 268 . 25 . 18898–904 . 1993 . 10.1016/S0021-9258(17)46711-1 . 8360179 . free .
• Morikawa Y, Hinata S, Tomoda H, etal . Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding . J. Biol. Chem. . 271 . 5 . 2868–73 . 1996 . 8576268 . 10.1074/jbc.271.5.2868 . free .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Zhou W, Resh MD . Differential membrane binding of the human immunodeficiency virus type 1 matrix protein . J. Virol. . 70 . 12 . 8540–8 . 1997 . 8970978 . 10.1128/JVI.70.12.8540-8548.1996. 190946 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .

See also

• Myristoylation
• N-myristoyltransferase 2

Notes and References

1. Duronio RJ, Reed SI, Gordon JI . Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae . Proc Natl Acad Sci U S A . 89 . 9 . 4129–33 . May 1992 . 1570339 . 525646 . 10.1073/pnas.89.9.4129 . 1992PNAS...89.4129D . free .
2. Web site: Entrez Gene: NMT1 N-myristoyltransferase 1.