N-myc-interactor explained

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.^{[1] [2] [3]}

Function

NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.^[3]

Interactions

NMI (gene) has been shown to interact with BRCA1, IFI35,^[4] Myc,^[5] and STAT5A,^[2] and TUBA3C.^[6]

Further reading

• Lebrun SJ, Shpall RL, Naumovski L . Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi. . J. Interferon Cytokine Res. . 18 . 9 . 767–71 . 1998 . 9781816 . 10.1089/jir.1998.18.767 .
• Lee ND, Chen J, Shpall RL, Naumovski L . Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain. . J. Interferon Cytokine Res. . 19 . 11 . 1245–52 . 1999 . 10574616 . 10.1089/107999099312902 .
• Bannasch D, Weis I, Schwab M . Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. . Oncogene . 18 . 48 . 6810–7 . 2000 . 10597290 . 10.1038/sj.onc.1203090 . free .
• Zhou X, Liao J, Meyerdierks A, etal . Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. . J. Biol. Chem. . 275 . 28 . 21364–71 . 2000 . 10779520 . 10.1074/jbc.M003177200 . free .
• Chen J, Shpall RL, Meyerdierks A, etal . Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35. . J. Biol. Chem. . 275 . 46 . 36278–84 . 2000 . 10950963 . 10.1074/jbc.M006975200 . free .
• Chen J, Naumovski L . Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. . J. Interferon Cytokine Res. . 22 . 2 . 237–43 . 2002 . 11911807 . 10.1089/107999002753536211 .
• Li H, Lee TH, Avraham H . A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. . J. Biol. Chem. . 277 . 23 . 20965–73 . 2002 . 11916966 . 10.1074/jbc.M112231200 . free .
• Sun GJ, Tong X, Dong Y, etal . [Identification of a protein interacting with apoptin from human leucocyte cDNA library by using yeast two-hybrid screening] . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao . 34 . 3 . 369–72 . 2002 . 12019454 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Jung HH, Lee J, Kim JH, etal . STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell. . FEBS Lett. . 579 . 18 . 3941–6 . 2005 . 15996661 . 10.1016/j.febslet.2005.06.011 . 23206849 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Schlierf B, Lang S, Kosian T, etal . The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi. . J. Mol. Biol. . 353 . 5 . 1033–42 . 2005 . 16214168 . 10.1016/j.jmb.2005.09.013 .
• Zhang L, Tang Y, Tie Y, etal . The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. . Cell. Signal. . 19 . 5 . 932–44 . 2007 . 17197158 . 10.1016/j.cellsig.2006.11.002 .
• Albihn A, Mo H, Yang Y, Henriksson M . Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling. . Int. J. Cancer . 121 . 8 . 1821–9 . 2007 . 17565738 . 10.1002/ijc.22866 . 22194144 . free .

Notes and References

1. Bao J, Zervos AS . Isolation and characterization of Nmi, a novel partner of Myc proteins . Oncogene . 12 . 10 . 2171–6 . Aug 1996 . 8668343 .
2. Zhu M, John S, Berg M, Leonard WJ . Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling . Cell . 96 . 1 . 121–30 . Mar 1999 . 9989503 . 10.1016/S0092-8674(00)80965-4 . 14758136 . free .
3. Web site: Entrez Gene: NMI N-myc (and STAT) interactor.
4. Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L . Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35 . J. Biol. Chem. . 275 . 46 . 36278–84 . November 2000 . 10950963 . 10.1074/jbc.M006975200 . free .
5. Li H, Lee TH, Avraham H . A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer . J. Biol. Chem. . 277 . 23 . 20965–73 . June 2002 . 11916966 . 10.1074/jbc.M112231200 . free .
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .