N-methylhydantoinase (ATP-hydrolysing) explained

N-methylhydantoinase (ATP-hydrolyzing)
Ec Number:	3.5.2.14
Cas Number:	100785-00-0
Go Code:	0047423

In enzymology, an N-methylhydantoinase (ATP-hydrolysing) is an enzyme that catalyzes the chemical reaction^[1]

ATP + N-methylimidazolidine-2,4-dione + 2 H₂O

\rightleftharpoons ADP + phosphate + N-carbamoylsarcosine

The 3 substrates of this enzyme are ATP, N-methylimidazolidine-2,4-dione, and H₂O, whereas its 3 products are ADP, phosphate, and N-carbamoylsarcosine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing). Other names in common use include N-methylhydantoin amidohydrolase, methylhydantoin amidase, N-methylhydantoin hydrolase, and N-methylhydantoinase. This enzyme participates in arginine, creatinine, and proline metabolism.

References

• Kim JM, Shimizu S, Yamada H . 1987 . Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis . Biochem. Biophys. Res. Commun. . 142 . 1006 - 12 . 3827889 . 10.1016/0006-291X(87)91514-2 . 3 .

Notes and References

1. Nucleoside triphosphate-dependent 1-methylhydantoinase, a process for obtaining it and the use - United States Patent 4816393.Inventors: Siedel Joachim, Deeg Rolf, Roder Albert, Ziegenhorn Joachim, Mollering Hans, Gauhl Helmgard.Assignee: Boehringer Mannheim.Application Date: 1985-02-25.Publication Date: 1989-03-28.