N-Methyl-L-glutamic acid explained

N-Methyl--glutamic acid (methylglutamate) is a chemical derivative of glutamic acid in which a methyl group has been added to the amino group. It is an intermediate in methane metabolism. Biosynthetically, it is produced from methylamine and glutamic acid by the enzyme methylamine—glutamate N-methyltransferase.[1] It can also be demethylated by methylglutamate dehydrogenase to regenerate glutamic acid.[2]

Notes and References

  1. 5905132 . 1966 . Shaw . WV . Tsai . L . Stadtman . ER . The enzymatic synthesis of N-methylglutamic acid . 241 . 4 . 935–45 . The Journal of Biological Chemistry. 10.1016/S0021-9258(18)96855-9 . free .
  2. 5028076 . 1972 . Hersh . LB . Stark . MJ . Worthen . S . Fiero . MK . N-methylglutamate dehydrogenase: Kinetic studies on the solubilized enzyme . 150 . 1 . 219–26 . Archives of Biochemistry and Biophysics . 10.1016/0003-9861(72)90029-X.

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