N-methyl-L-amino-acid oxidase explained

N-methyl-L-amino-acid oxidase
Ec Number:	1.5.3.2
Cas Number:	9029-23-6
Go Code:	0050131

In enzymology, a N-methyl-L-amino-acid oxidase is an enzyme that catalyzes the chemical reaction

an N-methyl-L-amino acid + H₂O + O₂

\rightleftharpoons an L-amino acid + formaldehyde + H₂O₂

The 3 substrates of this enzyme are N-methyl-L-amino acid, H₂O, and O₂, whereas its 3 products are L-amino acid, formaldehyde, and H₂O₂.

It has 2 cofactors: FAD, and Flavoprotein.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase.

Further reading

• Moritani M . 1952 . Demethylase. IV. Kinetics and reaction mechanism . Hukuoka Acta Med. . 43 . 651 - 658 .
• Moritani M . 1952 . Demethylase. V. Specificity and its relation to amino acid oxidase . Hukuoka Acta Med. . 43 . 731 - 735 .
• Moritani M, Tung TC, Fujii S, Mito H, Izumiya N, Kenmochi K, Hirohata R . Specificity of rabbit kidney demethylase . The Journal of Biological Chemistry . 209 . 2 . 485–92 . August 1954 . 13192101 .