N-methyl-2-oxoglutaramate hydrolase explained

N-methyl-2-oxoglutaramate hydrolase
Ec Number:	3.5.1.36
Cas Number:	9073-53-4
Go Code:	0050130

In enzymology, a N-methyl-2-oxoglutaramate hydrolase is an enzyme that catalyzes the chemical reaction

N-methyl-2-oxoglutaramate + H₂O

\rightleftharpoons 2-oxoglutarate + methylamine

Thus, the two substrates of this enzyme are N-methyl-2-oxoglutaramate and H₂O, whereas its two products are 2-oxoglutarate and methylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.

References

• Hersh LB . 1970 . 5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action . J. Biol. Chem. . 245 . 3526 - 35 . 5470822 . 14 .
• Hersh LB, Tsai L, Stadtman ER . 1969 . The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid . J. Biol. Chem. . 244 . 4677 - 83 . 5808511 . 17 .