| N-acetylneuraminate synthase | |
| Ec Number: | 2.5.1.56 |
| Cas Number: | 37290-66-7 |
| Go Code: | 0050462 |
| Width: | 270 |
In enzymology, a N-acetylneuraminate synthase is an enzyme that catalyzes the chemical reaction
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O
\rightleftharpoons
The 3 substrates of this enzyme are phosphoenolpyruvate, N-acetyl-D-mannosamine, and H2O, whereas its two products are phosphate and N-acetylneuraminate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming). Other names in common use include (NANA)condensing enzyme, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), and NeuAc synthase. This enzyme participates in aminosugars metabolism.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .