N-acetylneuraminate lyase explained

N-acetylneuraminate lyase
Ec Number:	4.1.3.3
Cas Number:	9027-60-5
Go Code:	0008747
Width:	270

The enzyme N-acetylneuraminate lyase catalyzes the chemical reaction

N-acetylneuraminate

\rightleftharpoons N-acetyl-D-mannosamine + pyruvate

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming). Other names in common use include N-acetylneuraminic acid aldolase, acetylneuraminate lyase, sialic aldolase, sialic acid aldolase, sialate lyase, N-acetylneuraminic aldolase, neuraminic aldolase, N-acetylneuraminate aldolase, neuraminic acid aldolase, N-acetylneuraminic acid aldolase, neuraminate aldolase, N-acetylneuraminic lyase, N-acetylneuraminic acid lyase, NPL, NALase, NANA lyase, acetylneuraminate pyruvate-lyase, and N-acetylneuraminate pyruvate-lyase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,, and .

References

• COMB DG, ROSEMAN S . 1960 . The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid . J. Biol. Chem. . 235 . 2529 - 37 . 13811398 .
• Schauer R . 1982 . Advances in Carbohydrate Chemistry and Biochemistry Volume 40; Chapter = Chemistry, Metabolism, and Biological Functions of Sialic Acids . Adv. Carbohydr. Chem. Biochem. . 40 . 131 - 234 . 6762816 . 10.1016/S0065-2318(08)60109-2 . Advances in Carbohydrate Chemistry and Biochemistry . 978-0-12-007240-8 .