N-acetylneuraminate 7-O(or 9-O)-acetyltransferase explained

N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
Ec Number:	2.3.1.45
Cas Number:	9054-50-6
Go Code:	0047186

In enzymology, a N-acetylneuraminate 7-O(or 9-O)-acetyltransferase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + N-acetylneuraminate

\rightleftharpoons CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate

Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its 3 products are CoA, N-acetyl-7-O-acetylneuraminate, and N-acetyl-9-O-acetylneuraminate.

Nomenclature

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase. Other names in common use include N-acetylneuraminate 7(8)-O-acetyltransferase, sialate O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, glycoprotein 7(9)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, and acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase.

References

• Schauer R . [Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse] . Hoppe-Seyler's Zeitschrift für Physiologische Chemie . 351 . 5 . 595–602 . May 1970 . 5446640 .
• Schauer R . [Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase] . Hoppe-Seyler's Zeitschrift für Physiologische Chemie . 351 . 6 . 749–58 . June 1970 . 5425947 . 10.1515/bchm2.1970.351.1.749 .