N-acetylglucosaminylphosphatidylinositol deacetylase explained
| N-acetylglucosaminylphosphatidylinositol deacetylase |
| Ec Number: | 3.5.1.89 |
| Go Code: | 0000225 |
In enzymology, a N-acetylglucosaminylphosphatidylinositol deacetylase is an enzyme that catalyzes the chemical reaction
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate
Thus, the two substrates of this enzyme are 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol and H2O, whereas its two products are 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol and acetate.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase. Other names in common use include N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase, N-acetylglucosaminylphosphatidylinositol de-N-acetylase, GlcNAc-PI de-N-acetylase, GlcNAc-PI deacetylase, and acetylglucosaminylphosphatidylinositol deacetylase. This enzyme participates in 3 metabolic pathways: glycosylphosphatidylinositol(gpi)-anchor, and glycan structures - biosynthesis 2.
References
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- Nakamura . N . 1997 . Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase . J. Biol. Chem. . 272 . 15834 - 40 . 9188481 . 10.1074/jbc.272.25.15834 . Inoue . N . Watanabe . R . Takahashi . M . Takeda . J . Stevens . VL . Kinoshita . T . 25 . free .
- Watanabe R, Ohishi K, Maeda Y, Nakamura N, Kinoshita T . Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis . Biochem. J. . 339 . 185 - 92 . 10085243 . 10.1042/0264-6021:3390185 . 1220143 .
- Smit TK . 2001 . Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors . EMBO J. . 20 . 3322 - 32 . 11432820 . 10.1093/emboj/20.13.3322 . Crossman . A . Borissow . CN . Paterson . MJ . Dix . A . Brimacombe . JS . Ferguson . MA . 13 . 125529 .
