N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase explained

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
Ec Number:	2.4.1.141
Cas Number:	75536-54-8

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase (UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase, uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase, N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol

\rightleftharpoons UDP + N,N'-diacetylchitobiosyl-diphosphodolichol

Notes and References

1. Sharma CB, Lehle L, Tanner W . Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast . European Journal of Biochemistry . 126 . 2 . 319–25 . August 1982 . 6215245 . 10.1111/j.1432-1033.1982.tb06781.x . free .
2. Turco SJ, Heath EC . Glucuronosyl-N-acetylglucosaminyl pyrophosphoryldolichol. Formation in SV40-transformed human lung fibroblasts and biosynthesis in rat lung microsomal preparations . The Journal of Biological Chemistry . 252 . 9 . 2918–28 . May 1977 . 192724 .