N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase explained

N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase
Ec Number:	3.1.4.45
Cas Number:	75788-84-0
Go Code:	0003944

The enzyme N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (EC 3.1.4.45)^{[1] [2] [3]} catalyzes the reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H₂O

\rightleftharpoons N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase. Other names in common use include α-N-acetylglucosaminyl phosphodiesterase, lysosomal α-N-acetylglucosaminidase, phosphodiester glycosidase, α-N-acetyl-D-glucosamine-1-phosphodiester, N-acetylglucosaminidase, 2-acetamido-2-deoxy-α-D-glucose 1-phosphodiester, and acetamidodeoxyglucohydrolase.

Notes and References

1. van der Drift C, van Helvoort PE, Vogels GD . 1971 . S-ureidoglycolate dehydrogenase: purification and properties . Arch. Biochem. Biophys. . 145 . 465 - 9 . 4399430 . 10.1016/S0003-9861(71)80006-1 . 2.
2. Van der Drift L, Vogels GD, Van der Drift C . 1975 . Allantoin racemase: a new enzyme from Pseudomonas species . Biochim. Biophys. Acta . 391 . 240 - 8 . 237557 . 1 . 10.1016/0005-2744(75)90170-9.
3. Waheed A, Hasilik A, von Figura K . 1981 . Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal α-N-acetylglucosaminyl phosphodiesterase . J. Biol. Chem. . 256 . 5717 - 21 . 6263889 . 11 .