N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase explained
| N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase |
| Ec Number: | 2.4.1.226 |
| Cas Number: | 269077-98-7 |
| Go Code: | 0050510 |
In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan
The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-, and proteoglycan, whereas its 3 products are UDP, beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-, and beta-D-glucuronosyl-proteoglycan.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase. This enzyme is also called chondroitin glucuronyltransferase II. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1.
References
- Kitagawa H, Uyama T, Sugahara K . 2001 . Molecular cloning and expression of a human chondroitin synthase . J. Biol. Chem. . 276 . 38721 - 6 . 11514575 . 10.1074/jbc.M106871200 . 42 . free .
- DeAngelis PL, Padgett-McCue AJ . 2000 . Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F . J. Biol. Chem. . 275 . 24124 - 9 . 10818104 . 10.1074/jbc.M003385200 . 31 . free .
- Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K . 2002 . Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4 . J. Biol. Chem. . 277 . 21567 - 75 . 11943778 . 10.1074/jbc.M201719200 . 24 . free .
- N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H . 2002 . Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine . J. Biol. Chem. . 277 . 38179 - 88 . 12145278 . 10.1074/jbc.M202601200 . 41 . free .
