N-acetylgalactosamine-4-sulfatase explained

N-acetylgalactosamine-4-sulfatase
Ec Number:	3.1.6.12
Cas Number:	55354-43-3

N-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase) is an enzyme with systematic name N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase.^{[1] [2] [3]} It catalyses the following reaction:

Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.

It also acts on N-acetylglucosamine 4-sulfate.

See also

• Arylsulfatase B

Notes and References

1. Farooqui AA . The desulphation of hexosamine sulphates by arylsulphatase B . Experientia . 32 . 10 . 1242–4 . October 1976 . 976430 . 10.1007/BF01953071 . 26640171 .
2. Gorham SD, Cantz M . Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide . Hoppe-Seyler's Zeitschrift für Physiologische Chemie . 359 . 12 . 1811–4 . December 1978 . 738706 . 10.1515/bchm2.1978.359.2.1811 .
3. Tsuji M, Nakanishi Y, Habuchi H, Ishihara K, Suzuki S . The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase . Biochimica et Biophysica Acta . 612 . 2 . 373–83 . April 1980 . 7370276 . 10.1016/0005-2744(80)90120-5 .