N-Desethylisotonitazene Explained

N-Desethylisotonitazene (norisotonitazene) is a benzimidazole opioid with potent analgesic effects which has been sold as a designer drug. It was first identified in 2023 as an active metabolite of the closely related compound isotonitazene, and was found to have similar potency. It is one of the strongest benzimidazole opioids discovered, with an analgesic strength 20 times stronger than fentanyl.

Starting in 2023, it has become an increasingly widespread drug of abuse in its own right, linked to numerous overdose cases, and may be considered an analog of the schedule 1 drug metonitazene. In October 2023, the DEA published an intent to temporarily schedule etonitazepipne and N-desethylisotonitazene. As of April 2024, it is not yet controlled in the United States.[1] [2] [3] [4] [5] [6] [7]

See also

Notes and References

  1. Krotulski AJ, Papsun DM, Kacinko SL, Logan BK . Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework . Journal of Analytical Toxicology . 44 . 6 . 521–530 . July 2020 . 10.1093/jat/bkaa016 . 32091095 . free .
  2. Vandeputte MM, Van Uytfanghe K, Layle NK, St Germaine DM, Iula DM, Stove CP . Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of "Nitazene" 2-Benzylbenzimidazole Synthetic Opioids . ACS Chemical Neuroscience . 12 . 7 . 1241–1251 . April 2021 . 10.1021/acschemneuro.1c00064 . 33759494 . 1854/LU-8714061 . 232337929 . free .
  3. Walton SE, Krotulski AJ, Logan BK . A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS) . Journal of Analytical Toxicology . 46 . 3 . 221–231 . March 2022 . 10.1093/jat/bkab117 . 34792157 . 8935987 .
  4. Vandeputte MM, Tsai MM, Chen L, Glatfelter GC, Walther D, Stove CP, Shi L, Baumann MH . 6 . Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide . Drug and Alcohol Dependence . 249 . 109939 . May 2023 . 10.1016/j.drugalcdep.2023.109939 . 37276825 . 10330921 . 258880063 .
  5. Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Mu-opioid Receptor Selective Superagonists ProduceProlonged Respiratory Depression. ISCIENCE (2023)
  6. Web site: Opioid 20x More Potent than Fentanyl Detected in Pennsylvania, Florida. . Taylor M . Forensic . 30 January 2023 .
  7. Web site: Federal Register :: Request Access . 25 October 2023 .

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