Acetylleucine Explained

Acetylleucine (N-acetyl-leucine) is a modified leucine amino acid.

Two forms are commercialized: N-acetyl-DL-leucine (sold under the brand Tanganil, among others, and used in the treatment of vertigo[1]) and N-acetyl-L-leucine (levacetylleucine, sold under the brand name Aqneursa, and used for the treatment of neurological manifestations of Niemann-Pick disease type C).[2]

Notes and References

  1. Web site: 19 Dec 2016 . N07CA04 (acetylleucine) . 26 Mar 2017 . WHO Collaborating Centre for Drug Statistics Methodology . Norwegian Institute of Public Health.
  2. Oertel . Wolfgang H. . Janzen . Annette . Henrich . Martin T. . Geibl . Fanni F. . Sittig . Elisabeth . Meles . Sanne K. . Carli . Giulia . Leenders . Klaus . Booij . Jan . Surmeier . D. James . Timmermann . Lars . Strupp . Michael . 2024-09-02 . Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports . Nature Communications . 15 . 1 . 7619 . 10.1038/s41467-024-51502-7 . 2041-1723 . 11369233 . 39223119.

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