N-Acetyllactosamine Explained

N-Acetyllactosamine (LacNAc) (also known as CD75) is a nitrogen-containing disaccharide,[1] a lactosamine derivative that is substituted with an acetyl group on its glucosamine component.

The N-acetyllactosamine is a component of many glycoproteins[2] and functions as a carbohydrate antigen that is thought to play roles in normal cellular recognition as well as in malignant transformation and metastasis.[3] It is also found in the structure of human milk oligosaccharides and has prebiotic effects.[4]

Notes and References

  1. Katzman RL . Isolation of N-Acetyllactosamine and Galactosyl-β-D-(1 → 4)-N-acetyllactosamine from Beef Brain Glycopeptides . The Journal of Biological Chemistry . 247 . 12 . 3744–9 . June 1972 . 10.1016/S0021-9258(19)45097-7 . 5033387 . free .
  2. Zhou D . Why are glycoproteins modified by poly-N-acetyllactosamine glyco-conjugates? . Current Protein & Peptide Science . 4 . 1 . 1–9 . February 2003 . 12570780 . 10.2174/1389203033380304 .
  3. Ito N, Yokota M, Nagaike C, Morimura Y, Hatake K, Matsunaga T . Histochemical demonstration and analysis of poly-N-acetyllactosamine structures in normal and malignant human tissues . Histology and Histopathology . 11 . 1 . 203–14 . January 1996 . 8720464 .
  4. Alavijeh MK, Meyer AS, Gras SL, Kentish SE . February 2020 . Simulation and economic assessment of large-scale enzymatic N-acetyllactosamine manufacture . Biochemical Engineering Journal . 154 . 107459 . 10.1016/j.bej.2019.107459. 214143153 .

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