N,α-Diethylphenethylamine explained

N,α-Diethylphenethylamine (N,α-DEPEA, 2-ethylamino-1-phenylbutane, EAPB) is a close chemical analog of methamphetamine, which has been sold as a designer drug.[1] [2] [3] It was originally patented by Knoll Pharma as one of several analogs for pharmaceutical applications. In animal models these analogs showed properties of cognitive enhancement and increased pain tolerance.[4] Nevertheless, this class of compounds was never developed into a medicine. has not been studied in humans, but experts such as Pieter Cohen of Harvard Medical School expect it to be less potent than methamphetamine, but greater than ephedrine.[5]

Adulterant in nutritional supplements

In January 2013, the South Korean authorities reported seizing a large quantity of the pure material, predicting it would soon be found on the market.[6] Later in 2013, it was found as an adulterant in biologically significant amounts in the pre-workout supplements Craze (marketed by Driven Sports, Inc.) and Detonate (marketed by Gaspari Nutrition).[4] [7] It was falsely claimed to be Dendrobium extract.[5] [8] [9]

See also

Notes and References

  1. Wójtowicz M, Jarek A, Chajewska K, Turek-Lepa E, Kwiatkowska D . Determination of designer doping agent--2-ethylamino-1-phenylbutane--in dietary supplements and excretion study following single oral supplement dose . Journal of Pharmaceutical and Biomedical Analysis . 115 . 523–33 . November 2015 . 26311473 . 10.1016/j.jpba.2015.07.025 .
  2. Uralets V, App M, Rana S, Morgan S, Ross W . Designer phenethylamines routinely found in human urine: 2-ethylamino-1-phenylbutane and 2-amino-1-phenylbutane . Journal of Analytical Toxicology . 38 . 2 . 106–9 . March 2014 . 24451085 . 10.1093/jat/bkt121 . free .
  3. Web site: 2-Ethylamino-1-phenylbutane . Cayman Chemical . 4 November 2015.
  4. 10.1007/s11419-013-0205-6. Identification and quantitation of N,α-diethylphenethylamine in preworkout supplements sold via the Internet. Forensic Toxicology. 32. 148–153. 2013. Lee J, Venhuis BJ, Heo S, Choi H, Seol I, Kim E . 41372093.
  5. Web site: Craze manufacturer disputes NSF's discovery of drug tainting . Nutraingredients . October 17, 2013.
  6. Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: A research chemical or a new designer drug? . Forensic Toxicology . 31 . 54–58 . January 2013. 10.1007/s11419-012-0158-1 . Lee J, Choe S, Choi H, Heo S, Kim E, Kim H, Bang E, Chung H . 13523048 .
  7. News: Popular sports supplements contain meth-like compound. USA Today . October 25, 2013 .
  8. Cohen PA, Travis JC, Venhuis BJ . A methamphetamine analog (N,α-diethyl-phenylethylamine) identified in a mainstream dietary supplement . Drug Testing and Analysis . 6 . 7–8 . 805–7 . 2014 . 24124092 . 10.1002/dta.1578 . 42232885 .
  9. http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=11156658 Warning issued over CRAZE sports supplement. New Zealand Herald, 13 November 2013

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