N,N'-diacetyllegionaminate synthase explained

N,N'-diacetyllegionaminate synthase
Ec Number:2.5.1.101

N,N'-diacetyllegionaminate synthase (neuB (gene), legI (gene)) is an enzyme with systematic name phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.[1] [2] This enzyme catalyses the following chemical reaction

2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O

\rightleftharpoons

N,N'-diacetyllegionaminate + phosphate

This enzyme requires a divalent metal such as Mn2+.

Notes and References

  1. Glaze PA, Watson DC, Young NM, Tanner ME . Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila . Biochemistry . 47 . 10 . 3272–82 . March 2008 . 18275154 . 10.1021/bi702364s .
  2. Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM . The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors . Glycobiology . 19 . 7 . 715–25 . July 2009 . 19282391 . 10.1093/glycob/cwp039 . free .

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